Class Meetings: Tuesdays and Thursdays, 11:00am-12:30pm, 36-112.
Instructors:
Peter Szolovits, PhD (psz@mit.edu)MIT LCS Clinical Decision Making Group Isaac Kohane, MD, PhD (isaac_kohane@harvard.edu)Children's Hospital Informatics Program Lucila Ohno-Machado, MD, PhD (machado@dsg.bwh.harvard.edu)BWH Decision Systems Group
Class Secretary:
Fern DeOliveira, (fernd@mit.edu)(617) 253-5860
Text:
Shortliffe EH, Perreault LE, Wiederhold G and Fagan LM, Medical Informatics: Computer Applications in Health Care and Biomedicine, 2nd Edition. Springer 2001.
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Schedule (tentative--subject to revision as we progress):
| Class | Date | Topic | Lecturer | Readings before class | Assignments |
|---|---|---|---|---|---|
| 1 | Feb. 4 | Introduction: Nature of Modern Medicine and Medical Practice
 (S)
(H) |
Peter Szolovits | Read Chapters 1 & 2 of Shortliffe. | |
| 2 | Feb. 6 | Nature of Medical Data: Where it is and Where it is Not
(S)
(H) |
Peter Szolovits | Read Chapters 9 & 10 of Shortliffe | |
| 3 | Feb. 11 | Genomics in Medicine: Centrality of Bioinformatics (S) | Isaac Kohane | Human Genome Project, Human Variation, Microarrays and Functional Genomics, Classification | |
| 4 | Feb. 13 | Patient Identification
(S)
(H) |
Peter Szolovits | Record Linkage Theory (optional) | HW1 out Other HW1 resources. |
| Feb. 18 | NO CLASS--Monday schedule of classes because of Presidents' Day | ||||
| 5 | Feb. 20 | Countering Bioterrorism (S) | Ken Mandl | Chapter 11 of Shortliffe | HW1 due |
| 6 | Feb. 25 | Workflow, Decision Support and Data Gathering
(S) |
Isaac Kohane | Workflow, ethnography, communication, integration | HW2 out |
| 7 | Feb. 27 | Computing Support for the Enterprise (PDF) (Audio) | John Glaser | ||
| 8 | Mar. 4 | Diagnosis, standards, codification
(S) |
Peter Szolovits | Chapters 6, 12 and 14 of Shortliffe | |
| 9 | Mar. 6 | Patient data confidentiality and security
(S) |
Peter Szolovits | Chapter 7 of Shortliffe and Privacy Confidentiality and EMR. Optional For the Record. | |
| 10 | Mar. 11 | Decreasing Variability in Health Care(S) | Lucila Ohno-Machado | HW2 due | |
| 11 | Mar. 13 | Computerized Physician Order Entry:
Using Technology To Improve Patient Safety
(H)
(PDF) |
David Bates | ||
| 12 | Mar. 18 | Integration and data sharing or
medical data for quality improvement
|
John Halamka | ||
| 13 | Mar. 20 | Telemedicine
(S) |
Hamish Fraser | Chapter 14 of Shortliffe | |
| Mar. 25 & 27 | NO CLASSES--MIT Spring Break | HW3 out | |||
|
14 |
Apr. 1 | Genomic Medicine I:
Population Genetics in the Post Genomic Era
(S) |
Marco Ramoni | Array of Hope, Complex Traits, SNPs and the Human Genome | Please see HW3addendum |
| 15 | Apr. 3 | Genomic Medicine II: Expression Arrays, Gene Clustering and Distance Metrics (S) |
Zoltan Szallasi | Support Vector Machines | HW3 due. Final Project Discussion Board |
| 16 | Apr. 8 | Decision analysis and decision support
|
Peter Szolovits | Chapters 15 and 16 of Shortliffe, Uncertainty in Medicine | Sign up for final presentation |
| 17 | Apr. 10 | Getting to Causality in Functional Genomics | Zak Kohane | Iyer99, Ramoni02 | Project proposals due |
| 18 | Apr. 15 | Advanced Expert Systems
(S) |
Peter Szolovits | Chapters 12 and 13 of Shortliffe | |
| 19 | Apr. 17 | Patient Monitoring
(S) |
Peter Szolovits | ||
| Apr. 22 | NO CLASS--Patriots Day Vacation | ||||
| 20 | Apr. 24 | Genomic Medicine III: Introduction to Genomics (PDF) |
Atul Butte | ||
| 21 | Apr. 29 | Genomic Medicine IV: Linking Genotypes and Phenotypes (S) |
Peter Park | ||
| 22 | May 1 | Genomic Medicine V: Reverse Engineering (S) |
Zoltan Szallasi | Genetic Networks (read chapter 5, page 23) | |
| 23 | May 6 | Student Presentations |
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| 24 | May 8 | Student Presentations |
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| 25 | May 13 | Student Presentations |
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| 26 | May 15 | Student Presentations |
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Legend for links in table:
= Media Player video (Windows only) = Real Player video (Windows only)We plan to give a handful of modest homework assignments to complement and reinforce material taught in the class. Links to the assignments (and, eventually, solutions) will appear in the schedule above. You must do the homework problems on your own. Of course you may ask for help and advice from classmates, but the final work that you turn in and all the words used to describe it must be your own.
The last four class sessions will be an opportunity for students to present the results of significant research projects done for the class. We encourage you to team up (in teams of two or three students) to work on projects, and teams that span students with different interests, skills and approaches are encouraged. Some reasonable illustrative project topics are listed here.
Conceptual Modeling & UML
Structured Query Language (SQL) and Relational Algebra