## MAPK-DKDP ##
# The distributed kinase and distributed phosphotase version of the MAP
# kinase model

% Compartments MAPK-DKDP
# There is no volume in this model, using 1 for volume
v	3	1

% Inputs v
E	1

% States v
S	2
E:S	0
M	0
E:M	0
D	0
P	1
P:D	0
P:M	0

% Outputs
S	S
M	M
D	D

% Parameters
k1on	0.02
k1off	1
k1cat	0.01
k2on	0.032
k2off	1
k2cat	15
k3on	0.045
k3off	1
k3cat	0.092
k4on	0.01
k4off	1
k4cat	0.5

% Reactions
E	S	E:S	0	k1on	k1off	E_+_S_<->_ES
E	M	E:S	0	0       k1cat	E_+_M_<-_ES
E	M	E:M	0	k2on    k2off	E_+_M_<->_EM
E	D	E:M	0	0       k2cat	E_+_D_<-_EM
P	D	P:D	0	k3on	k3off	P_+_D_<->_PD
M   P   P:D 0	0       k3cat   P_+_M_<-_PD
M	P	P:M	0	k4on	k4off	M_+_P_->_PM
P	S	P:M	0	0       k4cat	P_+_M_<->_PD