In vivo biosensors

Whether it is a specific cancer cell, stem cell or neuron, each cell state is characterized by a set of biomarkers: mRNA, proteins and microRNA.

We seek to engineer therapeutic and diagnostic genetic circuits that interface with cellular context and perform computation to decide the fate of a cell based on the integration of multiple biomarker sensors.

People: Lila Wroblewska; Zhen Xie; Jeremy Gam