Regulation Projects


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Mammalian synthetic transcriptional regulation

Recent advances in the engineering of DNA binding domains have opened up the possibility of greatly expanding orthogonal sets of transcriptional regulators. While bacterial promoters are relatively easy to manipulate, their mammalian counterparts can range from a few hundred base …


Micro-bio-robotic communication: Multicellular pattern formation and detection with visible and ultraviolet light

Our team proposes to develop a generalizable platform for the two-way interfacing of synthetic¬†biological systems with non-living systems. Important environmental signals such as explosives¬†(e.g., RDX and TNT), toxins, metals, salinity, pH, temperature and light, will be detected by¬†synthetic biosensors that …