Curriculum Vitae
Part
I: General Information
Date
prepared: February 14th 2005
Name Hamish S F
Fraser
Office
address: 643 Huntington
Avenue
Boston,
MA 02115
(T)
617-432-3930
(F)
617-432-6045
Home
Address: 16 Hill Street
Somerville,
MA, 02144
Email:
hamish_fraser@hms.harvard.edu
Education:
1991 MSc Edinburgh
University, Knowledge Based Systems
1990 MRCP Royal
College of Physicians, Medical Boards
1986 MB
ChB, Edinburgh University,
Medicine
1984 B.Sc. Edinburgh University,
Medical Science
Postdoctoral training:
1995-1999 Research/Clinical
Fellow New England
Medical Center, Boston
&
MIT Laboratory for Computer Science,
Cambridge,
MA
1992-1995 Career Registrar in Cardiology Edinburgh Royal Infirmary
and
Falkirk and
District Royal Infirmary, UK
1992 (6/12) Locum Registrar in Cardiology The
Freeman Hospital, Newcastle, UK
1989-1990 Senior House Officer in Medicine Northern General Hospital, Sheffield, UK
1988-1989 Senior House Officer in Medicine Stirling Royal Infirmary, Stirling,
UK
1987-1988 Senior House Officer in Medicine Falkirk and District Royal Infirmary,
UK
1986-1987 Internship Western General
Hospital, and
The Royal Infirmary, Edinburgh, UK
Licensure and certification:
1987 Full
medical license, United Kingdom
1998 Massachusetts
medical license (limited, dependent on visa type)
Academic appointments:
2003 – present Instructor in Medicine, Harvard Medical
School, Boston, MA
1999 – 2003 Instructor
in Pediatrics, Harvard Medical School
1995 – present Research Affiliate, MIT Laboratory for
Computer Science, Cambridge, MA
Hospital appointments :
2004 – present Research
Associate, Division of Social Medicine and Health Inequalities, Brigham and Women’s
Hospital
2000 – 2004 Research
Associate, Informatics Program, Children’s Hospital, Boston
Major administrative
responsibilities:
2002 – present
Director of cardiology Zamni
Lasante, Haiti
2000 – present Director of Informatics and Telemedicine, Partners
In Health,
Boston,
MA
2000 – present
Oversight of medical informatics and telemedicine Partners
In Health,
projects Socios
En Salud, Peru, Zanmi Lasante
1996 – 1999 Boston Informatics Research Trainees joint
lectures Harvard/MIT/Tufts
Informatics
Groups
Major Committee Assignments:
2003 Scientific program committee Helina2003 member International Medical
Informatics
Association
2002 – present Curriculum committee, Medical
Informatics MS program University of
KwaZuluNatal,
Durban
South
Africa
2001 – 2002 Informatics
working group for MDR-TB member Harvard/WHO/CDC
2001 – 2002 Working
group on DOTS-PLUS member WHO/CDC/HMS
Professional societies:
1996- present American
Medical Informatics Association Member
1990- present Royal
College of Physicians, Edinburgh Collegiate
member
1987 - 2001 British
Medical Association Member
1990 British
Medical Association Official
representative
Editorial Boards:
Part II: research, teaching, and clinical
contributions
Current Project:
I direct the development of
web-based medical record systems and data analysis tools to support the
treatment of drug resistant Tuberculosis in Peru, Haiti and Russia. The system
currently supports the management and monitoring of nearly 2000 patients in
treatment in Peru and 50 in Haiti. We have developed tools to search for
patterns in the bacteriology results for these patients and to graph this data
on the web. Extensive tools are provided to track the use of medication and
predict future requirements medication requirement, the largest single cost of
the treatment project. The system also provides tools to manage clinical data
and digital images of X-rays. I am performing clinical evaluation studies of
the system, including the impact of medication order entry by nurses on data
quality, and have shown a significant reduction of medication errors with this
approach (see bibliography).
A related project
(TeleMedMail), with my colleague and former student Darius Jazayeri, is a
system to facilitate store and forward telemedicine in developing countries. It
allows users to import images, modify them and add clinical data. These cases
are then compressed, encrypted and emailed to the specialist. Alternatively,
the archive can be sent to a server, the specialist then views the case over a
secure web connection. This system is operating in South Africa and a pilot
project of its use for HIV management is being set up. I have also performed an
evaluation of the diagnostic quality of digital images of X-rays acquired using
a low cost digital camera with my former student Agnieszka Szot. (see bibliography).
I am now developing a Web based
medical record system to support the treatment of HIV patients in rural Haiti.
The system is now operational and collecting data in very remote sites via
satellite link. Physicians are entering clinical data and medications directly
into the system, over 600 full records have been entered in the last 6 months.
Warning emails are generated nightly for low CD4 counts.
Informatics
fellowship project (MIT/NEMC)
I designed, set up and performed a clinical trial of the Heart Disease Program with physicians (mainly residents) at the New England Medical Center. We developed the user interface as a Web site to allow physicians to access the program over the Internet. 114 cases were directly entered by participating physicians and 50 entered over the Internet from around the world, many by cardiologists. The program showed better sensitivity than the resident physicians who entered the cases. I also developed new software tools and analyses to allow comparison of the performance of programs such as the Heart Disease Program that produce differential diagnoses (see bibliography and included papers).
Machine
Learning/Data Analysis
Several of my projects have used tools from
machine learning and statistics to develop decision support tools from data. I
started this area of work with Prof. Lee Kennedy in Edinburgh in 1992,
developing models to predict the diagnosis of myocardial infarction in patients
with chest pain. I continued this work with Bill Long and Chris Tsien at MIT
exploring ways to optimise decision trees induction, improve generalization of
models over data collected in different countries and to deal with missing data.
Patient Directed
Decision Support Tools
During 1998-99 I was funded by a grant from
the National Heart Attack Alert Program, an organization funded by the NIH to
explore ways to assist patients with myocardial infarction to recognise and act
quickly on their symptoms. I have assessed the performance of current patient
guidelines on data from Edinburgh and Boston to determine whether patients are
receiving optimum advice and developed new guidelines from data.
B. Funding information
2004 – 2009 NIH Co-Invest:
“ITGH Program in Sub-Saharan Africa”
(Fogarty
training grant)
2004 CDC PI: “Implementing a medical
record for MDR-TB
management
in the Philippines”
2003- 2006 NIH Co-Invest: “Ensemble for
Self-Scaling Systems for Health”
2001 – 2004 NIH Faculty:
“ITMI Program in Sub-Saharan Africa”
(Fogarty
training grant)
2000 – 2005 Gates Fdn. “Project for the eradication of MDR-TB in
Peru”
Primary
Investigator on the informatics sub-project
1999 – 2000 DARPA
Co-Invest: “High-Performance
Knowledge Bases Project”
1999 – 2000 NLM Co-Invest: “MAITA Project”
1998 – 1999 Pfizer
Inc. Co-Invest: “Detection of
adverse events in clinical trial data”
1998 – 1999 NIH/NHLBI Co-Invest: “Informatics for the National
Heart Attack Alert
program”
1995 – 1998 NIH/NHLBI Fellow:
“Clinical Evaluation of the Heart Disease Program”
C. Current research activities
the treatment of MDR-TB and HIV in developing countries
in developing countries
systems for
developing countries
programs
D. Report of teaching
1. Local Contributions
2003-2004
City University, London, UK
Co-Supervised a Master of Medical Informatics
student
2 hours/week
2002-2003
University of Colorado, Communications
Supervised a Master of
Engineering/Communications student
5 hours/week
2001-2002
Harvard/MIT HST
Supervised a Master of Medical Informatics
student
5 hours/week
2000-2002
MIT, Engineering
Supervised Master of Engineering student
5 hours/week
d. Invited teaching
presentations (as lecturer)
1999 –2004
Guest lecturer for the HST graduate course on
medical computing at MIT
2 hours per course plus preparation time.
November 1999
MIT graduate course on Artificial
Intelligence 6.034
Recitation: “Evaluating Medical Differential
Diagnosis Programs”
2 hours
March 1999
Medical Computing Course 6.872, MIT
2 hours
February 1998
Medical Computing Course 6.872, MIT
Lectured on “Developing Medical Decision
Support Tools with Logistic Regression”
2 hours
e. Advisory and supervisory responsibilities
2002
University of Natal, Durban, South Africa.
Designing and teaching a short course on
medical informatics for medical and research staff
60 hours
1998-1999
Cardiovascular Imaging Laboratory at New
England Medical Center, Boston
Teaching digital video production and editing
1 hour per week
1997 – 1999
Tufts University Medical School
Teaching clinical skills to medical students
2 hours per week
1988-1991
Edinburgh University Medical School
Teaching students and residents clinical
skills and procedures
10 hours per month
Current
2003 - 2004
University and Natal, Durban, South Africa
Designing and serving as educational director
of the first Masters degree course in Medical Informatics in Africa
160 hours/year
1. Regional, National or
International Contributions
a. Invited presentations
November
2004
WHO
Ministerial Summit on Health Research, Mexico City, Mexico
Invited
speaker and panelist
April 2004
Harvard/MIT Hippocratic society meeting on
International Health, Cambridge, MA
“Improving healthcare in developing countries
with good information”
Invited
lecture
March
2004
HIV
Patient ART Monitoring Meeting – WHO, Geneva, Switzerland
Invited expert.
October
2003
Helina2003: Communication and Information Technology
In the Global Fight against HIV/AIDS, Johannesburg, South Africa.
Two invited plenary lectures
April
2003
Haiti
Workshop on Expanding Aids Treatment, Care, and Prevention in Resource Poor
Settings
(sponsored
by the NIH Office of AIDS Research and the Rockefeller Foundation), Cange,
Haiti
Invited lecture
February
2003
Partnership for treatment of drug resistant
Tuberculosis, Lima, Peru,
Invited lecture
May 2001
The AMIA spring symposium, Atlanta, GA
Informatics for Public Health. Invited expert
June 2002
International Society for Equity in Health
(ISEqH) Second Annual Conference, University of Toronto,
invited lecture/workshop “ICTs for Disease
Prevention and Management: Beyond National
Boundaries” Invited workshop leader
May 2002
The AMIA spring symposium, Scotsdale Arizona,
“The
Role of Informatics in Drug Supply Management in Developing Countries”
Invited plenary lecture
June 2001
eHealth in Developing Countries, the Future
of Health Care? Cambridge, MA
Conference
chair
2000 and 2001
The Future of Health Technology Meeting, MIT
Media Lab, Cambridge, MA
Invited
lectures
July 2000
Internet Society Annual Meeting, Yokohama,
Japan
“Security
and Confidentiality of Medical Data on the Internet”. Invited lecture
April 2000
World Bank President James Wolfenson and the
staff of the “Infodev” program.
Invited to present ideas for the use of
information systems in healthcare in developing countries
March 2000
Harvard/MIT Hippocratic society meeting on
International Health, Cambridge, MA
“Informatics and Telemedicine in Sub-Saharan
Africa”.
Invited lecture
July 1999
Fogarty International Center ITMI program
Teaching short course on the use of the
Internet in African medicine in Durban, South Africa,
Invited lectures
Bibliography
1) Kennedy RL, Burton AM, Fraser HSF, McStay LN, Harrison RF.
Early Diagnosis of Acute Myocardial
Infarction Using Clinical and Electrocardiographic Data at Presentation:
Derivation and Evaluation of Logistic Regression Models
European Heart Journal, Vol. 17, August 1996,
p1181 – 91
2) Kennedy RL, Harrison RF,
Burton AM, Fraser HS, Hamer WG, MacArthur D, McAllum R,
Steedman DJ.
An Artificial Neural Network
System For Diagnosis Of Acute Myocardial Infarction (AMI) In The Accident And
Emergency Department: Evaluation And Comparison With Serum Myoglobin
Measurements.
Comput Methods Programs Biomed 1997
Feb;52(2):93-103
3) Fraser HSF, Kohane IS, Long WJ.
Using the Technology of the World Wide Web to
Manage Clinical Information
British Medical Journal, No 7094 Volume 314
Saturday 31 May 1997 P 1600-4
4) Long WJ, Fraser HSF, Naimi S.
Reasoning Requirements for Diagnosis of Heart Disease.
Artificial Intelligence in Medicine 10 (1997) pp. 5 – 24
5) Tsien CL, Fraser HS, Kohane IS.
LRTree: a hybrid technique for classifying myocardial infarction data containing unknown attribute values. Research and Development in Knowledge Discovery and Data Mining. Wu X, Kotagiri R, Korb KB, Eds., Lecture Notes in Artificial Intelligence 1394. Berlin Heidelberg: Springer-Verlag 1998: 409-411.
6) Hauskrecht M, Fraser
HS.
Planning treatment of
ischemic heart disease with partially observable Markov decision processes.
Artificial Intelligence in
Medicine, vol. 18, pp. 221-244, 2000
7) Wang SJ, Ohno-Machado L, Fraser HS,
Kennedy RL.
Using Patient-Reportable Clinical History
Factors to Predict Myocardial Infarction
Comput Biol Med. 2001 Jan 1;31(1):1-13.
8) Lober WB, Karras BT,
Wagner MM, Overhage MJ, Davidson AJ, Fraser HSF, Trigg LJ, Mandl KD,
Espino JU, Tsui FC.
Roundtable on Bioterrorism Detection: Information System-based
Surveillance.
J Am Med Inform Assoc. 2002 Mar-Apr;9(2):105-15.
9) Marques EP, Marin HF,
Massad E, Fraser H, Ohno-Machado L.
Training in health
informatics in Brazil.
Stud Health Technol Inform.
2002;90:757-60.
10) Fraser HSF, Long WJ, Naimi S.
Evaluation of a Cardiac Diagnostic Program in a Typical Clinical
Setting.
J Am Med Inform Assoc. 2003; Jul-Aug;10(4):373-81
11) Fine AM, Wong JB, Fraser HSF, Fleisher GR, Mandl KD.
Is It Influenza or Anthrax? A Decision Analytic Approach to the
Management of Patients with Influenza-Like Illnesses.
Ann. of Emerg. Med. 2004; 43(3): 318-328
11) Szot A, Jacobson F, Munn S, Jazayeri D, Nardell E, Harrison D,
Drosten R, Ohno-Machado L, Smeaton LM, Fraser HSF.
Diagnostic Accuracy of Chest X-rays Acquired Using a Digital Camera for
Low-Cost Teleradiology. Int. J. Med. Inform. 2004; 73(1): 65-73
13) Fraser HSF,
Jazayeri D, Nevil P, Karacaoglu Y, Farmer PE, Lyon E, Smith-Fawzi MK, Leandre
F, Choi S, Mukherjee JS.
An information
system and medical record to support HIV treatment in rural Haiti.
British Medical
Journal, 2004; 329;1142-1146
14) Laserson KF, Thorpe LE, Leimane V, Weyer K, Mitnick C, Riekstina V,
Zarovska E, Rich ML, Fraser HSF, Alarcon E, Cegielski JP, Grzemska M,
Gupta R, Espinal M.
Speaking the Same Language: Treatment Outcome Definitions for
Multidrug-Resistant Tuberculosis.
International Journal of Tuberculosis and Lung Disease, in press
1) Long WJ, Fraser HSF, Naimi S,
A Web Interface for the
Heart Disease Program
AMIA Fall Symposium, 1996, October ; Washington, DC. Hanley and Belfus;
1996. p. 762-6
Using Classification Tree
and Logistic Regression Methods to Diagnose Myocardial Infarction
MEDINFO 98, Seoul, Korea,
August 1998; Pt 1:493-7.
3) Fraser HSF, Long
WJ, Naimi S.
Differential Diagnoses of the Heart
Disease Program have better Sensitivity than Resident Physicians.
AMIA
Fall Symposium on Computer Applications in Health Care, 1998 November 7-11.
Orlando, Florida; Hanley and Belfus; 1998, p 622-26
Modelling Treatment of Ischemic Heart Disease with
Partially Observable Markov Decision Processes.
AMIA Fall Symposium on Computer Applications in Health Care, 1998
November 7-11. Orlando, Florida; Hanley and Belfus; 1998, p 538-42
5) Ohno-Machado L, Fraser HS, Ohrn A
Improving Machine Learning Performance by Removing Redundant Cases in
Medical Data Sets
AMIA Fall Symposium on
Computer Applications in Health Care, 1998 November 7-11. Orlando, Florida;
Hanley and Belfus; 1998, p 523-27
6) Fraser HSF, Long WJ,
Naimi S
New Approaches to Measuring the Performance of Programs that Generate
Differential Diagnoses using ROC Curves and Other Metrics.
Proc AMIA Symp. 2000;:255-9.
7) Fraser HS,
Jazayeri D, Bannach L, Szolovits P, McGrath SJ.
Telemedmail: free software to facilitate telemedicine in developing
countries.
Medinfo. 2001;10(Pt 1):815-9.
8) Fraser HSF,
Jazayeri D, Mitnick CD, Mukherjee JS, Bayona J
Informatics Tools To Monitor Progress And Outcomes Of Patients With Drug Resistant Tuberculosis In Peru.
Proc AMIA Symp.
2002: 270-274, San Antonio, Texas
9) Choi S, Jazayeri D,
Mitnick C, Chalco K, Pachao F, Bayona J, Fraser HSF.
A Web-based Nurse Order
Entry System for Multidrug-Resistant Tuberculosis Patients in Peru.
Proc. Medinfo2004, 11:
202-206
Fraser HSF, “Comparative
Physiology of the Basal Ganglia” [BSc Dissertation]
Edinburgh University,
Edinburgh, UK 1983.
Fraser HSF.,
"Qualitative Modelling of the Heart and Circulation [MSc Dissertation].
Edinburgh University, Edinburgh, UK, 1991.
Fraser HSF Medinfo-92 [conference
report], The Lancet, vol. 340: Sept. 26, 1992, pp 784.
Fraser HSF, McGrath JD
Information Technology and Telemedicine in
Sub-Saharan Africa [editorial]
BMJ. 2000 Aug 19-26;321(7259):465-6
Fraser HSF. Clinical information and
decision-support systems [book chapter]
In: Bruce McKenzie, editor. Medicine and the
Internet (third edition)
Oxford: Oxford University Press; 2002 p. 103 – 114.
Fraser HSF, Jazayeri D, Nevil P, Karacaoglu Y, Léandre F, Farmer PE, Mukherjee J. [book chapter]. In: Joia S. Mukherjee, editor. The PIH Guide to the Community-Based Treatment of HIV in Resource-Poor Settings
Boston: Partners In Health; 2004 p. 155 - 169
Letters in medical journals
Letters in newspapers
Abstracts
Yasin Z, Choi S, Fraser
HSF Improving Access To TB Medical Records In Remote Clinics In Peru Using
A Personal Digital Assistant Based Application
Proc AMIA Symp. 2002, San
Antonio, Tx, Hanley and Belfus; 2002 p 1207
Ohno-Machado L, Marin H, Marques
EP, Masssad E, Abrahao M, Fraser HSF
Training in Medical
Informatics in Northeastern Brazil
Proc AMIA Symp. 2002, San
Antonio, Tx, Hanley and Belfus; 2002 p 1118
Jazayeri D, Farmer P, Nevil
P, Mukherjee JS, Leandre F, Fraser HS
An Electronic Medical Record
System to Support HIV Treatment in Rural Haiti.
Proc AMIA Symp. 2003;:878.
Development and evaluation
of software to support prescribing and drug supply management in the treatment
of MDR-TB in Peru
Fraser HSF, Choi S,
Jazayeri D, Kempton K, Bayona J
Second International Conference on Improving the Use of Medicines, Chiang Mai, Thailand, March 30th – April 2nd 2004
McGraph SD, Fraser HSF,
Herbst K
Electronic Medical Record
(EMR) systems for HIV care in resource poor
settings: report from an
international workshop
A System For
Modeling Medication Requirements For the Management of Drug
Resistant Tuberculosis In Developing Countries
Fraser HSF, Jazayeri D,
Kempton K, Mosely M, Choi S, Pachao F, Bayona J
11th World Congress on
Medical Informatics, San Francisco, September 7 – 11, 2004
Proc. Medinfo2004,11: 1603